You can, but you'll need your wits about you as you've no camera view and you won't be able to see any warnings/alerts other than the limited set given by the aircraft status indicator.
If you want to see what it's like, then fly the I2 with the RC connected to your tablet, then disconnect the usb cable from the tablet. That way you can see what happens, but be able to restore the DJIGo control by plugging the cable back in.
I'd actually recommend everyone tries it at some point, if only to experience what happens when you fully loose your tablet/connection - worth it just so you don't panic when it happens unexepectedly
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